FDA says diabetes drug Byetta poses kidney risks

People with diabetes may want to use extra caution with the drug exenatide (Byetta). The Food and Drug Administration Monday added a warning about the risk of potentially life-threatening kidney problems to the package insert of the injectable diabetes drug.

The FDA said that from April 2005 through October 2008 it received 78 reports of kidney function problems, including 62 cases of kidney failure and four deaths, in people taking Byetta. The drug can cause nausea, vomiting, and diarrhea, and these might have contributed to the kidney problems, the FDA said.

If you or a loved one are taking Byetta, you should look for any symptoms that could indicate kidney problems. These include changes in urine color, frequency of urination or the amount of urine, unexplained swelling of the hands or feet, fatigue, changes in appetite or digestion, or a dull ache in the mid to lower back. If you notice any of these, discuss them with your doctor immediately.

—Steve Mitchell, associate editor, Consumer Reports Best Buy Drugs

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