Painkillers, prostate cancer and the PSA test
Many men remain undecided about whether to have the prostate-specific antigen (PSA) test for prostate cancer, as part of a routine health check. On the one hand, screening can detect cancers at an early stage; on the other, it may lead to needless investigations, and treatments that have risks of serious side effects. That's because many prostate cancers are very slow-growing and could safely be left undiagnosed and untreated.
Now a new study threatens to muddy the waters further. It suggests that men who regularly take aspirin, ibuprofen and other nonsteroidal anti-inflammatory drugs (NSAIDs) could have lower blood levels of PSA, the protein that is a marker for prostate cancer.
In the study, researchers looked at the PSA levels of more than 1,300 men over age 40. They found that men who used NSAIDs regularly had PSA levels that were around 10 percent lower than those of men who did not take these drugs.
The problem is, researchers don't know what this signifies. Do men who take these drugs run the risk of cancer not being detected because NSAIDs affect levels of PSA in their blood? Or do men who take NSAIDs have less of this protein because they are less likely to have prostate cancer?
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